Kit- and FcεRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells

The transmembrane adaptor protein (TRAP), NTAL, is phosphorylated in mast cells following FcεRI aggregation whereby it cooperates with LAT to induce degranulation. The Kit ligand, stem cell factor (SCF), enhances antigen-induced degranulation and this also appears to be NTAL-dependent. However, Kit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Iwaki, Shoko, Spicka, Jiri, Tkaczyk, Christine, Jensen, Bettina M., Furumoto, Yasuko, Charles, Nicolas, Kovarova, Martina, Rivera, Juan, Horejsi, Vaclav, Metcalfe, Dean D., Gilfillan, Alasdair M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2007
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329585/
https://ncbi.nlm.nih.gov/pubmed/17993265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.10.013
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