Kit- and FcεRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells

The transmembrane adaptor protein (TRAP), NTAL, is phosphorylated in mast cells following FcεRI aggregation whereby it cooperates with LAT to induce degranulation. The Kit ligand, stem cell factor (SCF), enhances antigen-induced degranulation and this also appears to be NTAL-dependent. However, Kit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Iwaki, Shoko, Spicka, Jiri, Tkaczyk, Christine, Jensen, Bettina M., Furumoto, Yasuko, Charles, Nicolas, Kovarova, Martina, Rivera, Juan, Horejsi, Vaclav, Metcalfe, Dean D., Gilfillan, Alasdair M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329585/
https://ncbi.nlm.nih.gov/pubmed/17993265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.10.013
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