Kit- and FcεRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells

The transmembrane adaptor protein (TRAP), NTAL, is phosphorylated in mast cells following FcεRI aggregation whereby it cooperates with LAT to induce degranulation. The Kit ligand, stem cell factor (SCF), enhances antigen-induced degranulation and this also appears to be NTAL-dependent. However, Kit...

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Detaylı Bibliyografya
Asıl Yazarlar: Iwaki, Shoko, Spicka, Jiri, Tkaczyk, Christine, Jensen, Bettina M., Furumoto, Yasuko, Charles, Nicolas, Kovarova, Martina, Rivera, Juan, Horejsi, Vaclav, Metcalfe, Dean D., Gilfillan, Alasdair M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329585/
https://ncbi.nlm.nih.gov/pubmed/17993265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.10.013
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