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A buried lysine that titrates with a normal pK(a): Role of conformational flexibility at the protein–water interface as a determinant of pK(a)values
Previously we reported that Lys, Asp, and Glu residues at positions 66 and 92 in staphylococcal nuclease (SNase) titrate with pK(a) values shifted by up to 5 pK(a) units in the direction that promotes the neutral state. In contrast, the internal Lys-38 in SNase titrates with a normal pK(a). The crys...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2327280/ https://ncbi.nlm.nih.gov/pubmed/18369193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073397708 |
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