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Buried lysine, but not arginine, titrates and alters transmembrane helix tilt

The ionization states of individual amino acid residues of membrane proteins are difficult to decipher or assign directly in the lipid–bilayer membrane environment. We address this issue for lysines and arginines in designed transmembrane helices. For lysines (but not arginines) at two locations wit...

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Detalhes bibliográficos
Main Authors: Gleason, Nicholas J., Vostrikov, Vitaly V., Greathouse, Denise V., Koeppe, Roger E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562795/
https://ncbi.nlm.nih.gov/pubmed/23319623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215400110
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