A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase.

Cyclins contain two characteristic cyclin folds, each consisting of five alpha-helical bundles, which are connected to one another by a short linker peptide. The first repeat makes direct contact with cyclin-dependent kinase (CDK) subunits in assembled holoenzyme complexes, whereas the second does n...

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Argitaratua izan da:	Mol Cell Biol
Egile Nagusiak:	Diehl, J A, Sherr, C J
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Taylor & Francis 1997
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232592/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9372967/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.12.7362
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