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Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo.

The adapter protein Shc is a critical component of mitogenic signaling pathways initiated by a number of receptors. Shc can directly bind to several tyrosine-phosphorylated receptors through its phosphotyrosine-binding (PTB) domain, and a role for the PTB domain in phosphotyrosine-mediated signaling...

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Published in:Mol Cell Biol
Main Authors: Ravichandran, K S, Zhou, M M, Pratt, J C, Harlan, J E, Walk, S F, Fesik, S W, Burakoff, S J
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1997
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232402/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9271429/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.9.5540
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