The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor.

Shc is an SH2 domain protein that is tyrosine phosphorylated in cells stimulated with a variety of growth factors and cytokines. Once phosphorylated, Shc binds the Grb2-Sos complex, leading to Ras activation. Shc can interact with tyrosine-phosphorylated proteins by binding to phosphotyrosine in the...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Batzer, A G, Blaikie, P, Nelson, K, Schlessinger, J, Margolis, B
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230680/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7542744/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.8.4403
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