Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation.

The functionality of the p53-mediated pathway, activated in response to DNA damage, has been assessed in primary fibroblast cell cultures and Epstein-Barr virus-transformed lymphoblastoid cell lines derived from Nijmegen breakage syndrome (NBS) patients. This autosomal recessive disease is character...

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Bibliografiske detaljer
Main Authors: Jongmans, W, Vuillaume, M, Chrzanowska, K, Smeets, D, Sperling, K, Hall, J
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC232352/
https://ncbi.nlm.nih.gov/pubmed/9271379
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