Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation.

The functionality of the p53-mediated pathway, activated in response to DNA damage, has been assessed in primary fibroblast cell cultures and Epstein-Barr virus-transformed lymphoblastoid cell lines derived from Nijmegen breakage syndrome (NBS) patients. This autosomal recessive disease is character...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Jongmans, W, Vuillaume, M, Chrzanowska, K, Smeets, D, Sperling, K, Hall, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232352/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9271379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.9.5016
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