Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia

A-kinase anchor protein 121 (AKAP121) assembles a multivalent signalling complex on the outer mitochondrial membrane that controls persistence and amplitude of cAMP and src signalling to mitochondria, and plays an essential role in oxidative metabolism and cell survival. Here, we show that AKAP121 l...

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Autors principals: Carlucci, Annalisa, Adornetto, Annagrazia, Scorziello, Antonella, Viggiano, Davide, Foca, Mariapaola, Cuomo, Ornella, Annunziato, Lucio, Gottesman, Max, Feliciello, Antonio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323260/
https://ncbi.nlm.nih.gov/pubmed/18323779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.33
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