Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling

A-kinase anchor protein 121 (AKAP121) and its spliced isoform AKAP84 anchor protein kinase A (PKA) to the outer membrane of mitochondria, focusing and enhancing cyclic AMP signal transduction to the organelle. We find that AKAP121/84 also binds PTPD1, a src-associated protein tyrosine phosphatase. A...

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Detalhes bibliográficos
Main Authors: Cardone, Luca, Carlucci, Annalisa, Affaitati, Adele, Livigni, Alessandra, deCristofaro, Tiziana, Garbi, Corrado, Varrone, Stelio, Ullrich, Axel, Gottesman, Max E., Avvedimento, Enrico V., Feliciello, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC416429/
https://ncbi.nlm.nih.gov/pubmed/15143158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.4613-4626.2004
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