Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.
Cross-linking of the B-cell antigen receptor (BCR) induces tyrosine phosphorylation of Shc, which is believed to lead to the activation of Ras. Previous work has shown that tyrosine-phosphorylated Shc forms complexes with another adapter protein, Grb2, and the Ras guanine nucleotide exchange factor...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232262/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9199344/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.7.4087 |
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