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Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.

Cross-linking of the B-cell antigen receptor (BCR) induces tyrosine phosphorylation of Shc, which is believed to lead to the activation of Ras. Previous work has shown that tyrosine-phosphorylated Shc forms complexes with another adapter protein, Grb2, and the Ras guanine nucleotide exchange factor...

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Udgivet i:Mol Cell Biol
Principais autores: Harmer, S L, DeFranco, A L
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232262/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9199344/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.7.4087
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