Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.

Cross-linking of the B-cell antigen receptor (BCR) induces tyrosine phosphorylation of Shc, which is believed to lead to the activation of Ras. Previous work has shown that tyrosine-phosphorylated Shc forms complexes with another adapter protein, Grb2, and the Ras guanine nucleotide exchange factor...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Harmer, S L, DeFranco, A L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232262/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9199344/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.7.4087
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