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Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome.

Trinucleotide repeat expansion is the causative mutation for a growing number of diseases including myotonic dystrophy, Huntington's disease, and fragile X syndrome. A (CTG/CAG)130 tract cloned from a myotonic dystrophy patient was inserted in both orientations into the genome of Saccharomyces cerev...

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Publicado no:Mol Cell Biol
Principais autores: Freudenreich, C H, Stavenhagen, J B, Zakian, V A
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232056/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9121457/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.4.2090
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