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Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome.

Trinucleotide repeat expansion is the causative mutation for a growing number of diseases including myotonic dystrophy, Huntington's disease, and fragile X syndrome. A (CTG/CAG)130 tract cloned from a myotonic dystrophy patient was inserted in both orientations into the genome of Saccharomyces...

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Autors principals: Freudenreich, C H, Stavenhagen, J B, Zakian, V A
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC232056/
https://ncbi.nlm.nih.gov/pubmed/9121457
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