Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome.

Trinucleotide repeat expansion is the causative mutation for a growing number of diseases including myotonic dystrophy, Huntington's disease, and fragile X syndrome. A (CTG/CAG)130 tract cloned from a myotonic dystrophy patient was inserted in both orientations into the genome of Saccharomyces cerev...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Freudenreich, C H, Stavenhagen, J B, Zakian, V A
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 1997
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9121457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.4.2090
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