Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome.
Trinucleotide repeat expansion is the causative mutation for a growing number of diseases including myotonic dystrophy, Huntington's disease, and fragile X syndrome. A (CTG/CAG)130 tract cloned from a myotonic dystrophy patient was inserted in both orientations into the genome of Saccharomyces cerev...
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| Gepubliceerd in: | Mol Cell Biol |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Taylor & Francis
1997
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9121457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.4.2090 |
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