Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase.

The K562 erythroleukemia cell line was used to study the molecular mechanisms regulating lineage commitment of hematopoietic stem cells. Phorbol esters, which initiate megakaryocyte differentiation in this cell line, caused a rapid increase in extracellular-signal-regulated kinase (ERK), which remai...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Whalen, A M, Galasinski, S C, Shapiro, P S, Nahreini, T S, Ahn, N G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232041/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9121442/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.4.1947
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