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The transcription factor E2F-1 is a downstream target of RB action.

Reintroduction of RB into SAOS2 (RB-/-) cells causes a G1 arrest and characteristic cellular swelling. Coexpression of the cellular transcription factor E2F-1 could overcome these effects. The ability of E2F-1 to bind to RB was neither necessary nor sufficient for this effect, and S-phase entry was...

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Udgivet i:Mol Cell Biol
Principais autores: Qin, X Q, Livingston, D M, Ewen, M, Sellers, W R, Arany, Z, Kaelin, W G
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231942/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7823942/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.2.742
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