Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.

Shc and insulin receptor substrate 1 (IRS-1) are cytoplasmic substrates of tyrosine kinase receptors that engage, localize, and activate downstream SH2 enzymes. Each contains a phosphotyrosine-binding (PTB) domain that is structurally unrelated to SH2 domains. We have designed high-affinity, cellula...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Giorgetti-Peraldi, S, Ottinger, E, Wolf, G, Ye, B, Burke, T R, Shoelson, S E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231843/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032245/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.3.1180
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