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Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.

Shc and insulin receptor substrate 1 (IRS-1) are cytoplasmic substrates of tyrosine kinase receptors that engage, localize, and activate downstream SH2 enzymes. Each contains a phosphotyrosine-binding (PTB) domain that is structurally unrelated to SH2 domains. We have designed high-affinity, cellula...

Täydet tiedot

Tallennettuna:
Julkaisussa:Mol Cell Biol
Päätekijät: Giorgetti-Peraldi, S, Ottinger, E, Wolf, G, Ye, B, Burke, T R, Shoelson, S E
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 1997
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231843/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032245/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.3.1180
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