p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression.

Cyclin E is necessary and rate limiting for the passage of mammalian cells through the G1 phase of the cell cycle. Control of cell cycle progression by cyclin E involves cdk2 kinase, which requires cyclin E for catalytic activity. Expression of cyclin E/cdk2 leads to an activation of cyclin A gene e...

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Bibliographic Details
Main Authors: Zerfass-Thome, K, Schulze, A, Zwerschke, W, Vogt, B, Helin, K, Bartek, J, Henglein, B, Jansen-Dürr, P
Format: Artigo
Language:Inglês
Published: 1997
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC231765/
https://ncbi.nlm.nih.gov/pubmed/8972221
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