p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression.
Cyclin E is necessary and rate limiting for the passage of mammalian cells through the G1 phase of the cell cycle. Control of cell cycle progression by cyclin E involves cdk2 kinase, which requires cyclin E for catalytic activity. Expression of cyclin E/cdk2 leads to an activation of cyclin A gene e...
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| Veröffentlicht in: | Mol Cell Biol |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
1997
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231765/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8972221/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.1.407 |
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