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p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression.

Cyclin E is necessary and rate limiting for the passage of mammalian cells through the G1 phase of the cell cycle. Control of cell cycle progression by cyclin E involves cdk2 kinase, which requires cyclin E for catalytic activity. Expression of cyclin E/cdk2 leads to an activation of cyclin A gene e...

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Udgivet i:Mol Cell Biol
Principais autores: Zerfass-Thome, K, Schulze, A, Zwerschke, W, Vogt, B, Helin, K, Bartek, J, Henglein, B, Jansen-Dürr, P
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231765/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8972221/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.1.407
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