CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers.

Optimal activation of T cells requires at least two signals delivered by the T-cell receptor complex and costimulatory molecules such as CD28. The CD28 signaling participates in the transcription of the interleukin-2 gene through activation of an enhancer termed the CD28-responsive element (CD28RE)....

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izdano v:	Mol Cell Biol
Principais autores:	Harhaj, E W, Maggirwar, S B, Good, L, Sun, S C
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis 1996
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231676/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943328/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.12.6736
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