CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers.

Samankaltaisia teoksia

• Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB.
  Tekijä: McKinsey, T A, et al.
  Julkaistu: (1996)
• Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factors.
  Tekijä: Maggirwar, S B, et al.
  Julkaistu: (1997)
• Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.
  Tekijä: White, D W, et al.
  Julkaistu: (1996)
• Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein.
  Tekijä: Begun, D J, et al.
  Julkaistu: (2000)
• Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation.
  Tekijä: Cheshire, J L, et al.
  Julkaistu: (1997)