Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.

The serine/threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus. Raf-1 integrates signals coming from extracellular factors and, in turn, activates its substrate, MEK kinase. MEK activates mitog...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Schulte, T W, Blagosklonny, M V, Romanova, L, Mushinski, J F, Monia, B P, Johnston, J F, Nguyen, P, Trepel, J, Neckers, L M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231585/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816498/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.10.5839
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