Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.

The serine/threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus. Raf-1 integrates signals coming from extracellular factors and, in turn, activates its substrate, MEK kinase. MEK activates mitog...

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Bibliografiske detaljer
Main Authors: Schulte, T W, Blagosklonny, M V, Romanova, L, Mushinski, J F, Monia, B P, Johnston, J F, Nguyen, P, Trepel, J, Neckers, L M
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC231585/
https://ncbi.nlm.nih.gov/pubmed/8816498
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