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Constitutive activation of Mek1 by mutation of serine phosphorylation sites.

A variety of extracellular signals lead to the phosphorylation and activation of mitogen-activated protein kinases (MAP kinases). An activator of MAP kinases, Mek1, phosphorylates MAP kinases at threonine and tyrosine residues and is itself phosphorylated at serine-218 and -222 by the protooncogene...

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Autors principals: Huang, W, Erikson, R L
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC44726/
https://ncbi.nlm.nih.gov/pubmed/8090753
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