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A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

Experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) residues 139–151 (HSLGKWLGHPDKF) can be prevented by treatment with a T cell receptor (TCR) antagonist peptide (L144/R147) generated by substituting at the two principal TCR contact residues in the encephal...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Nicholson, Lindsay B., Murtaza, Anwar, Hafler, Brian P., Sette, Alessandro, Kuchroo, Vijay K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23155/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9256473/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.17.9279
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