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A point mutation in the γ(2) subunit of γ-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity

Benzodiazepines allosterically modulate γ-aminobutyric acid (GABA) evoked chloride currents of γ-aminobutyric acid type A (GABA(A)) receptors. Coexpression of either rat γ(2) or γ(3), in combination with α(1) and β(2) subunits, results both in receptors displaying high [(3)H]Ro 15-1788 affinity. How...

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Bibliografiske detaljer
Main Authors: Buhr, Andreas, Sigel, Erwin
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23149/
https://ncbi.nlm.nih.gov/pubmed/9238062
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