A point mutation in the γ(2) subunit of γ-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity

Benzodiazepines allosterically modulate γ-aminobutyric acid (GABA) evoked chloride currents of γ-aminobutyric acid type A (GABA(A)) receptors. Coexpression of either rat γ(2) or γ(3), in combination with α(1) and β(2) subunits, results both in receptors displaying high [(3)H]Ro 15-1788 affinity. How...

Volledige beschrijving

Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Buhr, Andreas, Sigel, Erwin
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1997
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23149/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9238062/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.16.8824
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!