A point mutation in the γ(2) subunit of γ-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity
Benzodiazepines allosterically modulate γ-aminobutyric acid (GABA) evoked chloride currents of γ-aminobutyric acid type A (GABA(A)) receptors. Coexpression of either rat γ(2) or γ(3), in combination with α(1) and β(2) subunits, results both in receptors displaying high [(3)H]Ro 15-1788 affinity. How...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23149/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9238062/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.16.8824 |
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