The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability.

AML1 (also called PEBP2alphaB, CBFA2, or CBFalpha2) is one of the most frequently disrupted genes in chromosome abnormalities seen in human leukemias. It has been reported that AML1 plays several pivotal roles in myeloid hematopoietic differentiation and other biological phenomena, probably through...

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Detalhes bibliográficos
Main Authors: Tanaka, T, Kurokawa, M, Ueki, K, Tanaka, K, Imai, Y, Mitani, K, Okazaki, K, Sagata, N, Yazaki, Y, Shibata, Y, Kadowaki, T, Hirai, H
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC231393/
https://ncbi.nlm.nih.gov/pubmed/8668214
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