Low free energy cost of very long loop insertions in proteins

Long insertions into a loop of a folded host protein are expected to have destabilizing effects because of the entropic cost associated with loop closure unless the inserted sequence adopts a folded structure with amino- and carboxy-termini in close proximity. A loop entropy reduction screen based o...

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Bibliographic Details
Main Authors: Scalley-Kim, Michelle, Minard, Philippe, Baker, David
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2003
Subjects:
Accelerated Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312413/
https://ncbi.nlm.nih.gov/pubmed/12538883
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