Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

Critical to the proper maintenance of blood-brain-barrier (BBB) integrity are the endothelial tight junctions (TJs). Posttranslational modifications of essential endothelial TJ proteins, occludin and claudin-5, contribute and possibly disrupt BBB integrity. Our previous work has shown that Rho kinas...

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Detalhes bibliográficos
Main Authors: Yamamoto, Masaru, Ramirez, Servio H., Sato, Shinji, Kiyota, Tomomi, Cerny, Ronald L., Kaibuchi, Kozo, Persidsky, Yuri, Ikezu, Tsuneya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312373/
https://ncbi.nlm.nih.gov/pubmed/18187566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070076
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