Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

Neuroinflammatory conditions often involve dysfunction of the Blood-Brain Barrier (BBB). Therefore, identifying molecular targets that can maintain barrier fidelity is of clinical importance. We have previously reported on the anti-inflammatory effects that glycogen synthase kinase 3β (GSK3β) inhibi...

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Detalhes bibliográficos
Main Authors: Ramirez, Servio H., Fan, Shongshan, Dykstra, Holly, Rom, Slava, Mercer, Aaron, Reichenbach, Nancy L., Gofman, Larisa, Persidsky, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572160/
https://ncbi.nlm.nih.gov/pubmed/23418486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055972
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