Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood–brain barrier under physiologic and neuroinflammatory conditions

Blood–brain barrier (BBB) dysfunction seen in neuroinflammation contributes to mortality and morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. Identification of molecular targets maintaining barrier function is of clinical relevance. We used a novel in vivo model of...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Rom, Slava, Zuluaga-Ramirez, Viviana, Dykstra, Holly, Reichenbach, Nancy L, Ramirez, Servio H, Persidsky, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294393/
https://ncbi.nlm.nih.gov/pubmed/25248836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.167
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