Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood–brain barrier under physiologic and neuroinflammatory conditions

Blood–brain barrier (BBB) dysfunction seen in neuroinflammation contributes to mortality and morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. Identification of molecular targets maintaining barrier function is of clinical relevance. We used a novel in vivo model of...

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Détails bibliographiques
Publié dans:J Cereb Blood Flow Metab
Auteurs principaux: Rom, Slava, Zuluaga-Ramirez, Viviana, Dykstra, Holly, Reichenbach, Nancy L, Ramirez, Servio H, Persidsky, Yuri
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294393/
https://ncbi.nlm.nih.gov/pubmed/25248836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.167
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