Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood–brain barrier under physiologic and neuroinflammatory conditions

Blood–brain barrier (BBB) dysfunction seen in neuroinflammation contributes to mortality and morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. Identification of molecular targets maintaining barrier function is of clinical relevance. We used a novel in vivo model of...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Rom, Slava, Zuluaga-Ramirez, Viviana, Dykstra, Holly, Reichenbach, Nancy L, Ramirez, Servio H, Persidsky, Yuri
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294393/
https://ncbi.nlm.nih.gov/pubmed/25248836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.167
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