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Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis.

BCR-ABL is a deregulated tyrosine kinase expressed in Philadelphia chromosome-positive human leukemias. Prolongation of hematopoietic cell survival by inhibition of apoptosis has been proposed to be an integral component of BCR-ABL-induced chronic myelogenous leukemia. BCR-ABL elicits transformation...

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Bibliografske podrobnosti
Main Authors: Cortez, D, Kadlec, L, Pendergast, A M
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC230804/
https://ncbi.nlm.nih.gov/pubmed/7565705
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