Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.

Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two novel members of the mouse INK4 gene family, p19 and p18, that specifically inhibit the kinase activities of CDK4 and CDK6, but do not affect those of cyclin E-CDK2, cyclin...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Hirai, H, Roussel, M F, Kato, J Y, Ashmun, R A, Sherr, C J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230497/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7739547/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.5.2672
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