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Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein.

After exposure of cells to tumor necrosis factor (TNF), I kappa B alpha is rapidly degraded by a proteolytic activity that is required for nuclear localization and activation of transcription factor NF-kappa B. To investigate this problem, we have developed a cell-free system to study the degradatio...

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Bibliografiske detaljer
Main Authors: Rodriguez, M S, Michalopoulos, I, Arenzana-Seisdedos, F, Hay, R T
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC230470/
https://ncbi.nlm.nih.gov/pubmed/7739525
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