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The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation.

Labile mRNAs that encode cytokine and immediate-early gene products often contain AU-rich sequences within their 3' untranslated region (UTR). These AU-rich sequences appear to be key determinants of the short half-lives of these mRNAs, although the sequence features of these elements and the mechan...

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Udgivet i:Mol Cell Biol
Principais autores: Zubiaga, A M, Belasco, J G, Greenberg, M E
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230450/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7891716/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.4.2219
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