The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation.

Labile mRNAs that encode cytokine and immediate-early gene products often contain AU-rich sequences within their 3' untranslated region (UTR). These AU-rich sequences appear to be key determinants of the short half-lives of these mRNAs, although the sequence features of these elements and the mechan...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Zubiaga, A M, Belasco, J G, Greenberg, M E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230450/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7891716/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.4.2219
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