The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.
The AML-1/CBF beta transcription factor complex is targeted by both the t(8;21) and the inv(16) chromosomal alterations, which are frequently observed in acute myelogenous leukemia. AML-1 is a site-specific DNA-binding protein that recognizes the enhancer core motif TGTGGT. The t(8;21) translocation...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Mol Cell Biol |
|---|---|
| Prif Awduron: | , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Taylor & Francis
1995
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7891692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.4.1974 |
| Tagiau: |
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