The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.
The AML-1/CBF beta transcription factor complex is targeted by both the t(8;21) and the inv(16) chromosomal alterations, which are frequently observed in acute myelogenous leukemia. AML-1 is a site-specific DNA-binding protein that recognizes the enhancer core motif TGTGGT. The t(8;21) translocation...
Zapisane w:
| Wydane w: | Mol Cell Biol |
|---|---|
| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Taylor & Francis
1995
|
| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7891692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.4.1974 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|