The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.

The AML-1/CBF beta transcription factor complex is targeted by both the t(8;21) and the inv(16) chromosomal alterations, which are frequently observed in acute myelogenous leukemia. AML-1 is a site-specific DNA-binding protein that recognizes the enhancer core motif TGTGGT. The t(8;21) translocation...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Meyers, S, Lenny, N, Hiebert, S W
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7891692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.4.1974
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