Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

Activation of PERK following the accumulation of unfolded proteins in the endoplasmic reticulum (ER) promotes translation inhibition and cell cycle arrest. PERK function is essential for cell survival following exposure of cells to ER stress, but the mechanisms whereby PERK signaling promotes cell s...

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Bibliographic Details
Main Authors: Cullinan, Sara B., Zhang, Donna, Hannink, Mark, Arvisais, Edward, Kaufman, Randal J., Diehl, J. Alan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC230321/
https://ncbi.nlm.nih.gov/pubmed/14517290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.20.7198-7209.2003
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