Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo.

The persistence of transgene expression has become a hallmark for adenovirus vector evaluation in vivo. Although not all therapeutic benefit in gene therapy is reliant on long-term transgene expression, it is assumed that the treatment of chronic diseases will require significant persistence of expr...

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Hlavní autoři: Brough, D E, Hsu, C, Kulesa, V A, Lee, G M, Cantolupo, L J, Lizonova, A, Kovesdi, I
Médium: Artigo
Jazyk:Inglês
Vydáno: 1997
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC230223/
https://ncbi.nlm.nih.gov/pubmed/9371579
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